Cayman Amara Peptide (Trifluoroacetate Salt); 10 Mg; ≥95%

Nedaplatin is a derivative of cisplatin (Item No. ) with anticancer activity. Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death.^, It inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cells (IC₅₀s = 4.6 and 3.4 μM, respectively) and inhibits S to G₂ and G₂/M to G₁ cell cycle progression. Nedaplatin (44 mg/kg) decreases tumor volume and increases survival in a Lewis lung carcinoma syngeneic mouse model. Nedaplatin (40 mg/kg) also decreases tumor volume in an HNC-3 head and neck cancer mouse xenograft model. It exhibits reduced nephrotoxicity in rats compared with cisplatin.

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