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Cayman 10-Oxo-12(Z)-Octadecenoic Acid; 100 Μg; 103521-29-5; ≥95%
NETA PART: | CAYM-36977-100 |
MFG.PART: | 36977-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
10-oxo-12(Z)-Octadecenoic acid is a metabolite of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) and an activator of transient receptor potential vanilloid 1 (TRPV1).1,2 It is formed from linoleic acid by conjugated linoleic acid dehydrogenase (CLA-DH) via a 10-hydroxy-12(Z)-octadecenoic acid intermediate and can also be produced from linoleic acid by gut microbiota.1 10-oxo-12(Z)-Octadecenoic acid (100 µM) selectively increases calcium levels in HEK293 cells expressing TRPV1 over those expressing TRPV2, TRPV3, TRPV4, and TRP melastatin 8 (TRPM8).2 It also induces inward currents in HEK293 cells expressing TRPV1, an effect that can be blocked by the TRPV1 antagonist capsazepine (Item No. 10007518). Dietary administration of 10-oxo-12(Z)-octadecenoic acid (0.1% w/w) reduces weight gain and adipose tissue weight and increases the expression of the gene encoding mitochondrial uncoupling protein 1 (Ucp1) in wild-type, but not Trpv1 knockout, mice fed a high-fat diet. It also decreases plasma glucose and triglyceride levels in diabetic KKAy mice fed a high-fat diet.
WARNING This product is not for human or veterinary use.
Technical Information
- 10-keto-12Z-Octadecenoic Acid
- 10-oxo-12-cis-Octadecenoic Acid
- DMF: 10 mg/ml
- DMSO: 5 mg/ml
- Ethanol: 5 mg/ml
- PBS (pH 7.2): insol
Shipping & Storage Information
SKU | CAYM-36977-100 |
---|---|
Supplier Part Number | 36977-100 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
ProductLine | CAYM |
Qty | 100 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 103521-29-5 |