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Cayman Granzyme B Monoclonal Antibody; 100 Μl;
NETA PART: | CAYM-37067-100 |
MFG.PART: | 37067-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Granzyme B is a serine protease that is involved in cytotoxic T lymphocyte- and natural killer cell-induced cell death.1,2 It localizes to cytoplasmic granules prior to release into the immunological synapse formed with a target cell.3,1 Granzyme B cleaves its substrates after an aspartate residue and targets caspase-3, caspase-8, and gasdermin E (GSDME), among others.1,2 It is involved in caspase-dependent and -independent apoptosis, necrosis, DNA fragmentation, pyroptosis, viral infection, and antitumor immunity.1,2,4 Knockout of the gene encoding granzyme B, GZMB, reduces disease severity in a mouse model of epidermolysis bullosa acquisita, an autoimmune disease characterized by blistering of the skin.5 Serum and synovial levels of granzyme B are elevated in patients with rheumatoid arthritis.6 Cayman’s Granzyme B Monoclonal Antibody (Clone 2F5F2D10) can be used for ELISA and immunohistochemistry (IHC) applications.
WARNING This product is not for human or veterinary use.
Technical Information
- CTLA-1
- Cytotoxic Serine Protease B
- Cytotoxic T-lymphocyte Proteinase 2
- Fragmentin-2
- Granzyme-2
- GrB
Shipping & Storage Information
SKU | CAYM-37067-100 |
---|---|
Supplier Part Number | 37067-100 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
ProductLine | CAYM |
Qty | 100 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |