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Cayman VU0134992
Cayman VU0134992 - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$162.00
Your Price
$162.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-37299-10 |
| MFG.PART: | 37299-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
An internal standard for the quantification of glycochenodeoxycholic acid (GCDCA; Item No. ) by GC- or LC-MS. GCDCA is a glycine-conjugated form of the primary bile acid chenodeoxycholic acid (Item No. ). It reduces formation of cholic acid (Item No. ) in primary human hepatocytes when used at a concentration of 100 µM. GCDCA (50, 75, and 100 µM) reduces the number of LC3 puncta, a marker of autophagy, and is cytotoxic to L-02 hepatocytes. GCDCA (50 µM) induces apoptosis in isolated rat hepatocytes, an effect that can be blocked by the protein kinase C (PKC) inhibitor chelerythrine (Item No. ). Fecal levels of GCDCA are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(3α,5β,7α)-
CAS Number
1201918-16-2
Synonyms
- GCDCA-d4
Molecular Formula
C26H39D4NO5
Formula Weight
453.7
Purity
≥99% deuterated forms (d1-d4)
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
- Ethanol: 1 mg/ml
SMILES
C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1/i8D2,12D2
InChi Key
GHCZAUBVMUEKKP-PKIQRPOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-37299-10 |
|---|---|
| Supplier Part Number | 37299-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |