We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman Pdk1 (Human, Recombinant); 10 Μg; ≥85% Estimated By Sds-Page
Cayman Pdk1 (Human, Recombinant); 10 Μg; ≥85% Estimated By Sds-Page - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$360.00
Your Price
$360.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-37315-10 |
| MFG.PART: | 37315-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide (Item No. ) by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(butyl-
CAS Number
1219794-57-6
Synonyms
- D 860-d9
- U-2043-d9
Molecular Formula
C12H9D9N2O3S
Formula Weight
279.4
Purity
≥99% deuterated forms (d1-d9)
Formulation
A solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml
SMILES
CC1=CC=C(S(NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)(=O)=O)C=C1
InChi Code
InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)/i1D3,3D2,4D2,9D2
InChi Key
JLRGJRBPOGGCBT-ZYWCKPJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37315-10 |
|---|---|
| Supplier Part Number | 37315-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -80 |
| Refrigerated-Frozen | Frozen |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |