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Cayman ML-198
NETA PART: | CAYM-37755-10 |
MFG.PART: | 37755-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Derenofylline is an adenosine A1 receptor antagonist (Ki = 1 nM). It is selective for adenosine A1 over A2A, A2B, and A3 receptors (Kis = 398, 3,981, and 200 nM, respectively). It decreases adenosine A1 receptor-mediated adenosine-induced bradycardia in rats (ED50 = 0.49 mg/kg) but reduces A2 receptor-mediated adenosine-induced hypotension by only 44.6% when administered at an intravenous dose of 5 mg/kg. It prevents increases in heart levels of collagen I and III in nephrectomized rats when administered at a dose of 10 mg/kg per day. Derenofylline also reduces relative plaque counts in a Zika virus plaque-forming assay in A549 cells (IC50 = 58.6 nM) in an adenosine A1 receptor-independent manner without inducing cytotoxicity when used at concentrations less than 10 µM.
WARNING This product is not for human or veterinary use.
Technical Information
- SLV 320
- DMF: 1 mg/ml
- DMSO: 5 mg/ml
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- Ethanol: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-37755-10 |
---|---|
Supplier Part Number | 37755-10 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |