Cayman FABP4 Rabbit Monoclonal Antibody

Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein (iLBP) family.¹ It is composed of a β-barrel, which forms the lipid-binding site, and two α-helices that form a lid on the β-barrel.² FABP4 is primarily expressed in adipocytes but has also been found in activated macrophages.^3,4 It is involved in lipid transport and metabolism, insulin resistance, and angiogenesis, and its expression is induced by long-chain fatty acids and peroxisome proliferator-activated receptor γ (PPARγ) agonists.^1,5,6,7,8 Knockout of Fabp4 prevents the development of atherosclerosis in ApoE^-/- mice and increases body weight gain and insulin sensitivity in ob/ob mice.^9,5 Serum levels of FABP4 are increased in patients with colorectal cancer, and serum and synovial fluid levels of FABP4 are increased in patients with rheumatoid arthritis.^10,7 Cayman’s FABP4 Rabbit Monoclonal Antibody (Clone 001) can be used for flow cytometry (FC) and immunohistochemistry-paraffin (IHC-P) applications.

WARNING This product is not for human or veterinary use.