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Cayman MD2-TLR4-I
Cayman MD2-TLR4-I - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$316.00
Your Price
$316.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-38328-5 |
| MFG.PART: | 38328-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Doxofylline is a methylxanthine bronchodilator. It inhibits phosphodiesterase 2A1 (PDE2A1) and is an adenosine A2A receptor antagonist (IC50s = 0.74 and 0.9 mM, respectively). Doxofylline (10 µM) reduces superoxide production induced by LPS or PMA (Item No. ) in isolated human monocytes. It delays platelet-activating factor-induced bronchoconstriction in isolated guinea pig lungs when used at concentrations ranging from 0.28 to 1.5 mM. Doxofylline (1 mg/kg) inhibits LPS-induced neutrophil recruitment to the lungs and IL-6 and TNF-α release into bronchoalveolar fluid (BALF) in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7-(1,3-dioxolan-
CAS Number
69975-86-6
Synonyms
- ABC 12/3
- 2-(7-Theophyllinemethyl)-1,3-dioxolane
Molecular Formula
C11H14N4O4
Formula Weight
266.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 0.5 mg/ml
λmax
273 nm
SMILES
CN(C(N1C)=O)C2=C(N(CC3OCCO3)C=N2)C1=O
InChi Code
InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3
InChi Key
HWXIGFIVGWUZAO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-38328-5 |
|---|---|
| Supplier Part Number | 38328-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |