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Cayman 3-O-Anthraniloyl- 2-deoxyadenosine-5-O-triphosphate (sodium salt)
Cayman 3-O-Anthraniloyl- 2-deoxyadenosine-5-O-triphosphate (sodium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$189.00
Your Price
$189.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-38442-600 |
| MFG.PART: | 38442-600 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Item No. )., It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay. It induces DNA single-strand breaks in HT-29 colorectal adenocarcinoma cells when used at a concentration of 200 nM and cytotoxicity in HT-29 cells (IC50 = 8.8 nM). SN-38 (100 mg/kg per day) reduces tumor volume without affecting body weight in an MX-1 breast cancer mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(4S)-4,11-
CAS Number
86639-52-3
Synonyms
- 7-ethyl-10-hydroxy-20(S)-Camptothecin
- 7-ethyl-10-Hydroxycamptothecin
- NK 012
Molecular Formula
C22H20N2O5
Formula Weight
392.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 0.1 mg/ml
- DMSO: 2 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
SMILES
O=C([C@]1(O)CC)OCC2=C1C=C(C(N=C(C=CC(O)=C3)C3=C4CC)=C4C5)N5C2=O
InChi Code
InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChi Key
FJHBVJOVLFPMQE-QFIPXVFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-38442-600 |
|---|---|
| Supplier Part Number | 38442-600 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -80 |
| Refrigerated-Frozen | Frozen |
| ProductLine | CAYM |
| Qty | 600 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |