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Cayman 8-dimethylamino NAD+ (sodium salt)
NETA PART: | CAYM-38482-700 |
MFG.PART: | 38482-700 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin (Item No. ). While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses.,, Tin(IV) protoporphyrin IX chloride is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM)., It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). Tin(IV) protoporphyrin IX chloride prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. Tin(IV) protoporphyrin IX chloride is commonly used as a tool to study the role of HO-1 activity in cells and in animals.,
WARNING This product is not for human or veterinary use.
Technical Information
- NSC 267099
- SnPPIX
- DMF: 1 mg/ml
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- DMSO: 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-38482-700 |
---|---|
Supplier Part Number | 38482-700 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
ProductLine | CAYM |
Qty | 700 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |