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Cayman Ultrapure Water; Sz- 4 L
NETA PART: | CAYM-400000-4 |
MFG.PART: | 400000-4 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-κB activity, results in the development of some cancers and other diseases, making the development of IRAK inhibitors a potential therapeutic strategy. IRAK-1/4 inhibitor is a benzimidazole that disrupts the activity of IRAK-1 and -4 with IC50 values of 0.3 and 0.2 µM, respectively. It demonstrates IC50 values >10 µM in a panel of 27 other kinases tested. This compound has been used to inhibit a pro-inflammatory response in microglia isolated from clinically diagnosed Alzheimer’s disease patients.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 0.5 mg/ml
- DMSO: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-400000-4 |
---|---|
Supplier Part Number | 400000-4 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/400000m.pdf |
Temperature | 22 |
Refrigerated-Frozen | Ambient |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 4 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |