Cayman Kanamycin ELISA Standard

Roflumilast is an inhibitor of phosphodiesterase 4 (PDE4; IC₅₀ = 0.8 nM). It is selective for PDE4 over PDE1, -2, -3, and -5 (IC₅₀s = >10, >10, >10, and 8 µM, respectively). Roflumilast inhibits the production of leukotriene B₄ (LTB₄; Item No. ) induced by fMLP (Item No. ) in isolated human neutrophils with an IC₅₀ value of 2 nM. It reduces the proliferation of anti-CD3 and anti-CD28-stimulated isolated human CD4⁺ T cells (IC₃₀ = 7 nM). Roflumilast (5 mg/kg) prevents pulmonary inflammatory cell infiltration and emphysema in mice exposed to cigarette smoke. Formulations containing roflumilast have been used in the treatment of chronic obstructive pulmonary disease (COPD).

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