Cayman Benzodiazepine Elisa Standard

Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins.^,, Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is used as a therapeutic strategy to selectively target cancers.^, Rucaparib is a potent, cell-permeable inhibitor of PARP1 (K_i = <5 nM) that is used in clinical therapy to sensitize cancer cells to chemotherapy.^, Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC₅₀ values ranging from 1.3-5.5 μM. At 25 mg/kg, rucaparib arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors. It has been shown to increase efficacy of temozolomide in medulloblastoma cells and xenografts.

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