Cayman Cyclic Di-Amp Elisa Standard

Valsartan-d₉ is intended for use as an internal standard for the quantification of valsartan (Item No. ) by GC- or LC-MS. Valsartan is a nonpeptide antagonist of the angiotensin II type 1 (AT₁) receptor (IC₅₀ = 2.7 nM). It is 20,000-fold selective for AT₁ over AT₂ and, unlike some other AT receptor antagonists, does not alter peroxisome proliferator-activated receptor γ (PPARγ) activity in vitro. In vivo, valsartan (30 mg/kg) increases cardiac output and reduces left ventricular fibrosis in a model of heart failure with reduced ejection fraction in mice with streptozotocin-induced diabetes. Formulations containing valsartan have been used in the treatment of hypertension and heart failure.^,,

WARNING This product is not for human or veterinary use.