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Cayman Stat3 (Total) Tr-Fret Assay Kit
NETA PART: | CAYM-500202-4800 |
MFG.PART: | 500202-4800 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL., It is produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol (Item No. ) by the cytochrome P450 (CYP) isoform CYP7A1.,, 7-keto Cholesterol inhibits CYP7A1 (IC50 = ~1 μM). It induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state via NLRP3 inflammasome activation in vitro. Intraocular implantation of 7-keto cholesterol coated wafers increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye. Levels of 7-keto cholesterol in lipid deposits are increased in a variety of chronic diseases, including atherosclerosis, Alzheimers disease, and age-related macular degeneration.
WARNING This product is not for human or veterinary use.
Technical Information
- Δ5-Cholesterol-3β-ol-7-one
- 7-oxo Cholesterol
- SC-4722
- DMF: 2 mg/ml
- DMSO: 0.1 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
Shipping & Storage Information
SKU | CAYM-500202-4800 |
---|---|
Supplier Part Number | 500202-4800 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/500202m.pdf |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 4800 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |