We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman Tnf-Α (Human) Tr-Fret Biomarker Assay Kit
Cayman Tnf-Α (Human) Tr-Fret Biomarker Assay Kit - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$4,770.00
Your Price
$4,770.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-500234-4800 |
MFG.PART: | 500234-4800 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
GSK2578215A is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 8.9 nM) that also inhibits the G2019S mutant of LRRK2 (IC50 = 10.1 nM). It displays selectivity for LRRK2 over a panel of 460 other kinases. GSK2578215A prevents phosphorylation of both wild-type and G2019S LRRK2 in mouse spleen and kidney, but not in brain, following intraperitoneal injection of 100 mg/kg. GSK2578215A induces protective autophagy in SH-SY5Y cells and blocks LRRK2-dependent Na+/Ca2+ exchanger activity in dendritic cells.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(2-fluoro- 4-pyridinyl)- 2-(phenyl methoxy)-N-3- pyridinyl- benzamide
CAS Number
1285515-21-0
Molecular Formula
C24H18FN3O2
Formula Weight
399.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 1 mg/ml
λmax
271 nm
SMILES
O=C(C1=C(OCC2=CC=CC=C2)C=CC(C3=CC(F)=NC=C3)=C1)NC4=CC=CN=C4
InChi Code
InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)
InChi Key
WCIGMFCFPXZRMQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-500234-4800 |
---|---|
Supplier Part Number | 500234-4800 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 4800 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |