Cayman (В±)5(6)-Eet; Purity- Greater Than Or Equal To 95% (Mixtur

5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Item No. 90010) by cytochrome P450 enzymes.^1,2 In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.³ In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion.^4,5 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Ca_v3) that inhibits isoforms Ca_v3.1, Ca_v3.2 (IC₅₀ = 0.54 µM), and Ca_v3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Ca_v3.2 blockade when used at a concentration of 3 µM.⁶ In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM.⁷ (±)5(6)-EET is provided as a mixture of the free acid and lactone.

WARNING This product is not for human or veterinary use.