We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Cell-Based Assay 6-Methoxy-2-Naphthaldehyde Standard; Size
NETA PART: | CAYM-600094-5 |
MFG.PART: | 600094-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Eptapirone is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 4.8 nM in a radioligand binding assay). It is selective for 5-HT1A over other 5-HT receptor subtypes, dopamine D2 receptors, α1-adrenergic receptors, and histamine H1 receptors (Kis = <10,000, 1,770, 691.8, and <10,000 nM, respectively). Eptapirone inhibits cAMP stimulation induced by forskolin (Item No. ) in HA7 cells transfected with human 5-HT1A receptors (EC50 = 158 nM). In vivo, eptapirone increases extracellular 5-HT (Item No. ) in the ventral hippocampus of rats (ED50 = 0.049 mg/kg) and serum corticosterone (Item No. ) levels when administered p.o. or i.p. (ED50s = 0.16 and 0.057 mg/kg, respectively). It decreases immobility in rats in a forced swim test and increases punished responding in a pigeon conflict procedure, demonstrating antidepressant-like and anxiolytic activity. Eptapirone (2.5 mg/kg, p.o.) also attenuates hypertension and tachycardia induced by sibutramine (Item No. ) in rats with no effect on sibutramine-induced hypophagia.
WARNING This product is not for human or veterinary use.
Technical Information
- F 11440
- DMF: 10 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS (pH 7.2) (1:40): 0.025 mg/ml
- Ethanol: slightly soluble
Shipping & Storage Information
SKU | CAYM-600094-5 |
---|---|
Supplier Part Number | 600094-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/600094m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |