Cayman D-Myo-Inositol-1,3,4,5-Tetraphosphate (Sodium Salt); Purit

Anandamide (arachidonoyl ethanolamide; AEA) is an endogenous lipid with cannabinergic activity; along with 2-arachidonoyl glycerol, it forms part of the endocannabinoid system.^, AEA undergoes reuptake into neurons by a facilitated process. Controversy exists as to whether there is a specific AEA transporter, or instead the uptake process is simply driven by hydrolysis of AEA by intracellular fatty acyl amide hydrolase (FAAH).^, CAY10412 is an analog of AEA that has no intrinsic binding affinity for either CB₁ or CB₂ receptors. It is a potent inhibitor of AEA reuptake in U937 lymphoma cells, with an IC₅₀ of 3 µM. CAY10412 could be a useful tool for distinguishing the competing transporter theories. The pharmacology of CAY10412 is largely unexplored; it may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations.

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