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Cayman Sc-58125; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
Cayman Sc-58125; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$17.00
Your Price
$17.00
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| NETA PART: | CAYM-70655-1 |
| MFG.PART: | 70655-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
ABBV-744 is an inhibitor of the bromodomain and extra-terminal domain (BET) family protein bromodomain 2 (BD2; Kis = 4.6, 4.9, 1.6, and 1 nM for BRD2, -3, -4, and -T, respectively). It is selective for BD2 over BD1 bromodomains in a time-resolved FRET (TR-FRET) assay (Kis = 1,162, 3,140, 521, and 917 nM for BRD2, -3, -4, and -T, respectively). ABBV-744 inhibits proliferation of SKM-1 leukemia cells (IC50 = 6.7 nM). It induces cell cycle arrest at the G1 phase in LNCaP prostate cancer cells. ABBV-744 (18.8 mg/kg) reduces tumor volume in a SKM-1 mouse xenograft model. It also reduces tumor growth in LNCaP and MDA PCa 2b mouse xenograft models when administered at doses of 1 and 4.7 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide |
| CAS Number | 2138861-99-9 |
| Molecular Formula | C28H30FN3O4 |
| Formula Weight | 491.6 |
| Purity | ≥98% |
| Formulation | A crystalline solid |
| Solubility |
|
| SMILES | CC(C)(O)C1=CC=C(OC2=C(C)C=C(F)C=C2C)C(C3=CN(C)C(C4=C3C=C(C(NCC)=O)N4)=O)=C1 |
| InChi Code | InChI=1S/C28H30FN3O4/c1-7-30-26(33)22-13-20-21(14-32(6)27(34)24(20)31-22)19-12-17(28(4,5)35)8-9-23(19)36-25-15(2)10-18(29)11-16(25)3/h8-14,31,35H,7H2,1-6H3,(H,30,33) |
| InChi Key | OEDSFMUSNZDJFD-UHFFFAOYSA-N |
| Storage | -20°C |
| Shipping | Wet ice in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-70655-1 |
|---|---|
| Supplier Part Number | 70655-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/70655m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 162054-19-5 |