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Cayman Lycopene; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-70945-5 |
MFG.PART: | 70945-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
SB-743921 is a potent inhibitor of the kinesin spindle protein Eg5 (Ki = 0.5 nM for microtubule-stimulated ATPase activity). It inhibits the growth of HCT116 colon, LNCaP and PC3 prostate, K562 leukemia, BxPC-3 pancreas, and NCI-H1299 lung cancer cell lines in vitro (GI50s = 25, 22, 48, 50, 80, and 82 nM, respectively). In vivo, SB-743921 induces complete tumor regression in a COLO 205 mouse xenograft model and partial regression in MCF-7, SK-MES, H69, and OVCAR-3 mouse xenograft models. SB-743921 (2.5-10 mg/kg) also reduces tumor volume in a dose-dependent manner in a diffuse large B cell lymphoma (DLBCL) mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 50 mg/ml
- DMSO: 50 mg/ml
- Ethanol: 20 mg/ml
- PBS (pH 7.2): 0.2 mg/ml
Shipping & Storage Information
SKU | CAYM-70945-5 |
---|---|
Supplier Part Number | 70945-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/70945m.pdf |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 502-65-8 |