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Cayman Ppoh; Purity- Greater Than Or Equal To 99%; Size- 5 Mg
Cayman Ppoh; Purity- Greater Than Or Equal To 99%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$78.00
Your Price
$78.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-75760-5 |
| MFG.PART: | 75760-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.,,, 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-bromo-
CAS Number
4906-68-7
Synonyms
- NSC 109116
Molecular Formula
C13H9BrO3
Formula Weight
293.1
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 15 mg/ml
- DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml
- DMSO: 12.5 mg/ml
- Ethanol: 0.1 mg/ml
λmax
233, 326 nm
SMILES
BrC1=CC(C2=CC=CC=C2)=CC(C(O)=O)=C1O
InChi Code
InChI=1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17)
InChi Key
XVZSXNULHSIRCQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-75760-5 |
|---|---|
| Supplier Part Number | 75760-5 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/75760m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 206052-01-9 |