Cayman S-Ethyl Isothiourea (Hydrobromide); Purity- Greater Than O

SKL2001 is an activator of Wnt/β-catenin signaling.^, It increases β-catenin responsive transcription in a cell-based reporter assay in a concentration-dependent manner, increases β-catenin protein levels in HEK293 cells when used at concentrations of 10 and 30 μM, and disrupts the interaction between Axin and β-catenin. SKL2001 increases alkaline phosphatase (ALP) activity and mineralization in multipotent mesenchymal ST2 cells in a concentration-dependent manner, indicating increased osteoblastogenesis. SKL2001 (40 μM) reduces HCT116 and HT-29 spheroid growth and inhibits proliferation of HCT116 and HT-29 cells. It induces cell cycle arrest at the G₀/G₁ phase and increases E-cadherin and β-catenin protein levels in HCT116 cells when used at a concentration of 40 μM.

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