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Cayman Oleoyl Serotonin-D17; Purity- Greater Than Or Equal To 99%
Cayman Oleoyl Serotonin-D17; Purity- Greater Than Or Equal To 99% Deuterated Forms (D1-D17); Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$274.00
Your Price
$274.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-9000694-1 |
| MFG.PART: | 9000694-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
NMS-E973 is an inhibitor of heat shock protein 90 (HSP90; IC50 = 10 nM in a fluorescence polarization assay). It decreases HER2 protein expression (IC50 = 110 nM) in BT474 breast cancer cells and inhibits the growth of a 16 cancer cell line panel (IC50s = 13-362 nM)., NMS-E973 (60 mg/kg, i.v., per day for ten days) reduces tumor growth by 74% in an A2780 xenograft mouse model. It reduces expression of HSP90 client proteins, phosphorylated ERK and AKT, and total AKT in lysates from A2780 tumors. NMS-E973 also completely eradicates MOLM-13 acute myeloid leukemia tumors in a mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[2,4-di
CAS Number
1253584-84-7
Molecular Formula
C22H22N4O7
Formula Weight
454.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
λmax
304 nm
SMILES
OC1=CC(OC2=CC=C([N+]([O-])=O)C=C2)=C(C3=CC(C(NC4CCN(C)CC4)=O)=NO3)C(O)=C1
InChi Code
InChI=1S/C22H22N4O7/c1-25-8-6-13(7-9-25)23-22(29)17-12-20(33-24-17)21-18(28)10-15(27)11-19(21)32-16-4-2-14(3-5-16)26(30)31/h2-5,10-13,27-28H,6-9H2,1H3,(H,23,29)
InChi Key
YLQODGGPIHWTHR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-9000694-1 |
|---|---|
| Supplier Part Number | 9000694-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/9000694m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |