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Cayman Atipamezole (Hydrochloride); Purity- Greater Than Or Equal
NETA PART: | CAYM-9001181-10 |
MFG.PART: | 9001181-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Vaborbactam is an inhibitor of β-lactamases (Kis = 29-110 nM for class A and class C enzymes). It is selective for bacterial β-lactamases over a panel of mammalian serine proteases (IC50s = ≥1,000 μM). Vaborbactam potentiates the activity of biapenem against K. pneumonia expressing the β-lactamase KPC-2, reducing the MIC value for biapenem from 32 to 1 μg/ml when used at a concentration of 0.02 μg/ml. It also potentiates the activity of the carbapenem antibiotics biapenem, meropenem (Item No. ), ertapenem, and imipenem (Item No. ) against clinical isolates of E. coli, E. cloacae, K. oxytoca, and K. pneumoniae that produce serine β-lactamases (MICs = ≤0.06-4 and 4-64 μg/ml in the presence and absence of vaborbactam, respectively). In vivo, vaborbactam (50 mg/kg) reduces the number of colony forming units (CFUs) in the lung in a neutropenic mouse lung infection model when used in combination with biapenem or meropenem. Formulations containing vaborbactam in combination with meropenem have been used for the treatment of carbapenem-resistant Enterobacteriaceae infections.
WARNING This product is not for human or veterinary use.
Technical Information
- RPX 7009
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 10 mg/ml
- PBS (pH 7.2): 1 mg/ml
Shipping & Storage Information
SKU | CAYM-9001181-10 |
---|---|
Supplier Part Number | 9001181-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/9001181m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 104075-48-1 |