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Cayman (S)-()-Docosahexaenyl-2-Hydroxy-1-Propylamide; Purity- G
NETA PART: | CAYM-9001231-5 |
MFG.PART: | 9001231-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
SR 18292 is an inhibitor of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), a coactivator of transcription factors for genes involved in gluconeogenesis. SR 18292 (20 µM) increases acetylation of PGC-1α and, subsequently, decreases mRNA expression of phosphoenolpyruvate carboxykinase 1 (PEPCK1/Pck1) and the glucose-6-phosphatase catalytic subunit (G6Pc) in primary hepatocytes following stimulation with glucagon. In a dietary model of type II diabetes mellitus in mice, SR 18292 (45 mg/kg, i.p., for four days) reduces fasting blood glucose levels and the expression of liver Pck1. It also enhances glucose tolerance and insulin sensitivity in two mouse models of obesity.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 25 mg/ml
- DMSO: 25 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- Ethanol: 10 mg/ml
Shipping & Storage Information
SKU | CAYM-9001231-5 |
---|---|
Supplier Part Number | 9001231-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/9001231m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |