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Cayman Gsk805; Purity- Greater Than Or Equal To 98%; Size- 10 Mg
NETA PART: | CAYM-9002444-10 |
MFG.PART: | 9002444-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptors putative ligand binding domain without exerting significant effects on DNA binding.1 It inhibits the expression of IL-17 (at 0.5 µM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 3 mg/ml
- DMSO: 5 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
Shipping & Storage Information
SKU | CAYM-9002444-10 |
---|---|
Supplier Part Number | 9002444-10 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/9002444m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1426802-50-7 |