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Cayman 2-Nonylquinolin-4(1h)-One, 25 Mg
Cayman 2-Nonylquinolin-4(1h)-One, , 25 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$142.00
Your Price
$142.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-9003627-25 |
| MFG.PART: | 9003627-25 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. Acetyl podocarpic acid anhydride (APD) is a potent, semisynthetic LXR agonist derived from extracts of the mayapple. APD acting through LXR in concert with the retinoid X receptor (RXR), its heterodimerization partner, induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol (ED50 value of 1 nM). In transient transactivation assays, APD was found to be approximately 1,000 times more potent and have 8-10-fold greater maximal stimulation of LXR than 22(R)-hydroxy cholesterol., APD can be used as a positive control for the testing of LXR agonists, which have potential as therapeutic agents for the treatment of atherosclerosis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-
CAS Number
344327-48-6
Synonyms
- Acetylpodocarpic dimer
- APD
Molecular Formula
C38H46O7
Formula Weight
614.8
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 1 mg/ml
λmax
208, 268 nm
SMILES
CC(=O)Oc1ccc2CC[C@H]3[C@](C)(CCC[C@]3(C)c2c1)[C@@H](=O)O[C@H](=O)[C@@]1(C)CCC[C@]2(C)c3cc(ccc3CC[C@@H]12)OC(=O)C
InChi Code
InChI=1S/C38H46O7/c1-23(39)43-27-13-9-25-11-15-31-35(3,29(25)21-27)17-7-19-37(31,5)33(41)45-34(42)38(6)20-8-18-36(4)30-22-28(44-24(2)40)14-10-26(30)12-16-32(36)38/h9-10,13-14,21-22,31-32H,7-8,11-12,15-20H2,1-6H3/t31-,32-,35-,36-,37+,38+/m1/s1
InChi Key
OUJQRQRBNRGQTC-SPGSYPTKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-9003627-25 |
|---|---|
| Supplier Part Number | 9003627-25 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/9003627m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 55396-45-7 |