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Cayman 3-Methoxyphenylacetone; Size- 5 Mg
NETA PART: | CAYM-9003643-5 |
MFG.PART: | 9003643-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Esculetin is a coumarin that has been found in Euphorbia and has diverse biological activities.,,,, It inhibits 5-lipoxygenase (5-LO) and 12-LO (IC50s = 4 and 2.5 µM, respectively), as well as the histone demethylase jumonji AT-rich interactive domain 1B (JARID1B; IC50 = 4.6 µM)., Esculetin is active against B. cereus, S. lutea, S. aureus, S. lactis, A. faecalis, and E. coli. It reduces production of hydrogen peroxide induced by the leucin-rich repeat kinase 2 (LRRK2) mutant LRRK2G2019S, which is linked to neurotoxicity and Parkinson’s disease, in Drosophila brain lysates and decreases cell death in LRRK2G2019S-expressing primary human cortical neurons. Esculetin (1.68 µmol/ear) reduces croton oil-induced ear edema in mice. It also inhibits acetylcholine-induced writhing in mice (ED50 = 69 mg/kg).
WARNING This product is not for human or veterinary use.
Technical Information
- Aesculetin
- Cichorigenin
- 6,7-Dihydroxycoumarin
- NSC 26427
- DMF: 50 mg/mL
- DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 2 mg/mL
Shipping & Storage Information
SKU | CAYM-9003643-5 |
---|---|
Supplier Part Number | 9003643-5 |
UM | UN |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/9003643m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 3027-13-2 |