We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman FEN1-IN-4
Cayman FEN1-IN-4 - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$286.00
Your Price
$286.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-37790-10 |
MFG.PART: | 37790-10 |
UNSPSC: | 12352100 |
Manufacturer: | Cayman |
Product Description
FEN1-IN-4 is an inhibitor of flap endonuclease 1 (FEN1; IC50 = 30 nM for FEN1-336Δ).1 It also inhibits exonuclease 1 in a concentration-dependent manner. FEN1-IN-4 (10 µM) inhibits ATP-induced mitochondrial DNA (mtDNA) fragmentation and levels of cytosolic mtDNA in LPS-primed primary mouse bone marrow-derived macrophages (BMDMs).2 It also inhibits ATP-induced phosphorylation of STING in LPS-primed wild-type and Nlrp3-/- primary mouse BMDMs. FEN1-IN-4 (40 mg/kg) decreases peritoneal levels of IL-1β and neutrophil and monocyte infiltration in a mouse model of alum-induced peritonitis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name | 1-(cyclopropylmethyl)-3-hydroxy-2,4(1H,3H)-quinazolinedione |
CAS Number | 1995893-58-7 |
Synonyms |
|
Molecular Formula | C12H12N2O3 |
Formula Weight | 232.2 |
Purity | ≥98% |
Formulation(Request formulation change) | A solid |
Solubility(Learn about Variance in Solubility) |
|
SMILES | O=C1C2=C(N(CC3CC3)C(N1O)=O)C=CC=C2 |
InChi Code | InChI=1S/C12H12N2O3/c15-11-9-3-1-2-4-10(9)13(7-8-5-6-8)12(16)14(11)17/h1-4,8,17H,5-7H2 |
InChi Key | JAFLWTUYSKADJS-UHFFFAOYSA-N |
Storage | -20°C |
Shipping | Room Temperature in continental US; may vary elsewhere |
Stability | ≥ 4 years |
SKU | CAYM-37790-10 |
---|---|
Supplier Part Number | 37790-10 |
UM | EA |
UNSPSC | 12352100 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/37790m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1995893-58-7 |