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Cayman EZ Cap™ Firefly Luciferase mRNA (mo5U)
NETA PART: | CAYM-39801-100 |
MFG.PART: | 39801-100 |
UNSPSC: | 12352202 |
Manufacturer: | Cayman |
Product Description
NVP-BEP800 is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 58 nM for recombinant human Hsp90β). It is selective for Hsp90 over the chaperones GRP94 and TRAP1 (IC50s = 4.1 and 5.5 µM, respectively). NVP-BEP800 inhibits the growth of BT474, SK-BR-3, MCF-7, MDA-MB-157, MDA-MB-231, MDA-MB-468, and BT-20 breast cancer cells (GI50s = 53, 56, 118, 89, 190, 173, and 162 nM, respectively). It reduces levels of the Hsp90 target proteins HER2 and Raf-1 in MCF-7 cells. NVP-BEP800 induces apoptosis and attenuates X-ray-induced increases in Hsp70 levels in T98G glioblastoma cells. NVP-BEP800 (15-50 mg/kg) reduces tumor volume in A375 melanoma and BT474 breast cancer mouse xenograft models. It also reduces tumor volume in an L1T2 Kaposi sarcoma mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 12 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- Ethanol: 5 mg/mL
Shipping & Storage Information
SKU | CAYM-39801-100 |
---|---|
Supplier Part Number | 39801-100 |
UM | EA |
UNSPSC | 12352202 |
Manufacturer | Cayman |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |