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Cayman TNF-β (human, recombinant)
NETA PART: | CAYM-40210-100 |
MFG.PART: | 40210-100 |
UNSPSC: | 12352202 |
Manufacturer: | Cayman |
Product Description
TNF-β, also known as lymphotoxin-α (LT-α), is a cytokine and member of the TNF and TNF receptor (TNFR) cytokine superfamily.1 It is produced as an N-glycosylated peptide that forms soluble bell-shaped homotrimers after signal peptide cleavage.2,3 TNF-β also forms cell surface-anchored heterotrimers with TNF-C, also known as lymphotoxin-β (LT-β).3 It is expressed in T cells, natural killer (NK) cells, and B cells, as well as macrophages. When secreted, TNF-β homotrimers bind to TNF-α receptor 1 (TNFR1) and TNFR2 while TNF-β-LT-β heterotrimers bind to the LT-β receptor.1,4,2 Through activation of these receptors, TNF-β is involved in lymphoid organ development and maintenance, host defense, and inflammatory processes.3,1 TNF-β induces proliferation of fibroblast-like synoviocytes isolated from patients with rheumatoid arthritis, and levels of TNF-β are increased in the serum and synovial fluid of patients with rheumatoid arthritis.5 SNPs in LTA, the gene encoding TNF-β in humans, are associated with various diseases, including systemic lupus erythematosus (SLE) and cancer.6,7 Cayman’s TNF-β (human, recombinant) protein can be used for cellular activity assays. The protein was synthesized from a DNA sequence encoding the mature form of human TNF-β (Leu35-Leu205) with an N-terminal translation-initiating methionine (Met1). The expressed protein consists of 172 amino acids, has a calculated molecular weight of 18.8 kDa, and a predicted N-terminus of Met1.
WARNING This product is not for human or veterinary use.
Technical Information
- LTA
- LT-α
- Lymphotoxin-α
- TNFSF1
- Tumor Necrosis Factor-β
- Tumor Necrosis Factor Ligand Superfamily Member 1
Shipping & Storage Information
SKU | CAYM-40210-100 |
---|---|
Supplier Part Number | 40210-100 |
UM | EA |
UNSPSC | 12352202 |
Manufacturer | Cayman |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |