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Cayman Soluble Fas Ligand/CD95 Ligand (human, recombinant; aa 134-281)
NETA PART: | CAYM-40212-50 |
MFG.PART: | 40212-50 |
UNSPSC: | 12352202 |
Manufacturer: | Cayman |
Product Description
Fas ligand (FasL), also known as CD95L, is a type II transmembrane protein and member of the TNF superfamily.1 It is composed of a cytoplasmic domain, transmembrane domain, stalk region, TNF homology domain (THD), which is involved in homotrimerization, and Fas-binding domain. FasL is expressed in activated T cells, as well as the placenta, testis, lung, prostate, esophagus, uterus and spleen.2 Binding of FasL to its receptor Fas leads to formation of a death-inducing signaling complex (DISC) composed of CD95 oligomers, the Fas-associated death domain protein (FADD), and procaspase-8, procaspase-10, and cellular FLICE-like inhibitory protein (c-FLIP), which induces apoptosis.3 Soluble FasL (sFasL) is produced by proteolytic cleavage of FasL by various matrix metalloproteinases (MMPs) and either inhibits FasL-induced apoptosis or induces apoptosis in a context-dependent manner.1,4 sFasL induces migration of isolated human neutrophils and apoptosis in primary human distal lung epithelial cells.5,6 It decreases ankylosis in a rat model of collagen-induced arthritis.7 Serum levels of sFasL are increased in patients with insulin-dependent diabetes mellitus, systemic lupus erythematosus (SLE), rheumatoid arthritis, gastric cancer, or leukemia. Cayman’s Soluble Fas Ligand/CD95 Ligand (human, recombinant; aa 134-281) protein can be used for binding assays. This protein consists of 168 amino acids and has a calculated molecular weight of 19.3 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 26 kDa due to glycosylation.
WARNING This product is not for human or veterinary use.
Technical Information
- CD178
- CD95L
- FasL
- FASLG
- TNFL6
- TNF Ligand Superfamily Member 6
- TNFSF6
- Tumor Necrosis Factor Ligand 6
Shipping & Storage Information
SKU | CAYM-40212-50 |
---|---|
Supplier Part Number | 40212-50 |
UM | EA |
UNSPSC | 12352202 |
Manufacturer | Cayman |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |