Cayman 3-O-(5-Bromoanthraniloyl)-2-deoxyguanosine-5-O-triphosphate (sodium salt)

Salubrinal is a selective phosphatase inhibitor that prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF_2α), protecting PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC₅₀ = 15 μM).^, It appears to block the action of protein phosphatase 1 (PP1) on eIF_2α although it does not mimic calyculin A, another PP1-selective inhibitor, in toxicity or phosphorylation pattern. Salubrinal also prevents replication of herpes virus (IC₅₀ = 3 μM), by inhibiting dephosphorylation of eIF_2α. As eIF_2α has a role in bone formation, salubrinal is being studied for its effects in osteoporosis.

WARNING This product is not for human or veterinary use.