Cayman 2(3)-O-(5-Chloroanthraniloyl)guanosine-5-O-triphosphate (sodium salt)

GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI).^, ML-184 is a potent synthetic agonist of GPR55 (EC₅₀ = 0.26 µM). It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB₁ and CB₂ (IC₅₀s = 21.8 and 15.1 µM, respectively). Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.

WARNING This product is not for human or veterinary use.