Cayman GPX1 (human, recombinant)

Glutathione peroxidase 1 (GPX1) is a selenocysteine-containing glutathione peroxidase with antioxidant activity.¹ It is ubiquitously expressed and localizes to both the cytosol and mitochondria.² GPX1 catalyzes the reduction of hydrogen peroxide, hydroperoxy fatty acids, and hydroperoxy lysophosphatides to water or their corresponding non-toxic lipid alcohols, respectively, by converting glutathione (GSH) to oxidized glutathione (GSSG), thereby reducing intracellular oxidative stress.^1,2,3 GPX1 levels are increased in renal cell carcinoma tumors compared with non-tumor renal tissue and correlated with decreased overall patient survival.⁴ Plasma levels of GPX1 are decreased in asthmatic patients and GPX1 SNPs are associated with an increased risk of the development of asthma.⁵ Cardiac GPX1 levels and whole blood GPX1 activity are decreased in patients with Keshan disease, an endemic cardiomyopathy associated with low selenium levels in the soil and food supply.⁶ Caymans GPX1 (human, recombinant) protein can be used for enzyme activity assays.

WARNING This product is not for human or veterinary use.