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Cayman Ganoderenic Acid D
Cayman Ganoderenic Acid D - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$383.00
Your Price
$383.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-39774-5 |
| MFG.PART: | 39774-5 |
| UNSPSC: | 12352100 |
| Manufacturer: | Cayman |
Product Description
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization., It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs)., NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to block polyspermy and activate embryogenesis. NAADP-induced calcium mobilization induces VEGF-mediated angiogenesis in human umbilical vein endothelial cells (HUVECs). It also alkalizes lysosomal pH thereby inhibiting fusion between autophagosomes and lysosomes and arresting autophagic flux in mouse embryonic stem cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2′-(dihydrogen phosphate), adenosine 5′-
Synonyms
- Nicotinic Acid adenine dinucleotide phosphate
Molecular Formula
C21H23N6O18P3 • 4Na
Formula Weight
832.3
Purity
≥95%
Formulation
A solid
Solubility
- Water: 50 mg/ml
λmax
259 nm
SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C([O-])=O)=CC=C5)O4)([O-])=O)([O-])=O)O3.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C21H27N6O18P3.4Na/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(44-46(33,34)35)14(29)11(43-20)6-41-48(38,39)45-47(36,37)40-5-10-13(28)15(30)19(42-10)26-3-1-2-9(4-26)21(31)32;;;;/h1-4,7-8,10-11,13-16,19-20,28-30H,5-6H2,(H6-,22,23,24,31,32,33,34,35,36,37,38,39);;;;/q;4*+1/p-4/t10-,11-,13-,14-,15-,16-,19-,20-;;;;/m1..../s1
InChi Key
NWKIGVGTZIAOCW-MCNGMCCKSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-39774-5 |
|---|---|
| Supplier Part Number | 39774-5 |
| UM | EA |
| UNSPSC | 12352100 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/39774m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 100665-43-8 |