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Cayman SCDase (Shewanella alga, recombinant)
NETA PART: | CAYM-38256-0.25 |
MFG.PART: | 38256-0.25 |
UNSPSC: | 12352202 |
Manufacturer: | Cayman |
Product Description
Simvastatin-d6 is intended for use as an internal standard for the quantification of simvastatin (Item Nos. | ) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid leukemia cells. It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells. Formulations containing simvastatin have been used in the treatment of dyslipidemias.
WARNING This product is not for human or veterinary use.
Technical Information
- SVA-d6
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 20 mg/ml
Shipping & Storage Information
SKU | CAYM-38256-0.25 |
---|---|
Supplier Part Number | 38256-0.25 |
UM | EA |
UNSPSC | 12352202 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/38256m.pdf |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |