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Cayman Tat-Gap 19 (trifluoroacetate salt)
Cayman Tat-Gap 19 (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$575.00
Your Price
$575.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-36729-5 |
| MFG.PART: | 36729-5 |
| UNSPSC: | 12352100 |
| Manufacturer: | Cayman |
Product Description
Tat-Gap 19 is a peptide inhibitor of connexin43 (Cx43) hemichannels.1 It is composed of the HIV-1 Tat protein transduction domain linked to a nine-amino acid peptide corresponding to residues 128-136 of Cx43. Tat-Gap 19 (10 µM) inhibits glutamate-induced ATP release, a marker of Cx43 hemichannel activity, in primary rat hepatocytes.2 It reduces infarct volume in a mouse model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 25 mg/kg.1 Intraperitoneal infusion of Tat-Gap 19 (1 mg/kg per day) reduces fibrotic lesion area and the area of hepatic stellate cells, precursors of myofibroblasts, expressing α-smooth muscle actin (α-SMA) in a mouse model of thioacetamide-induced liver injury.2 It increases superoxide dismutase (SOD) activity in hepatic cells isolated from the same mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
L-tyrosylglycyl-
Molecular Formula
C119H212N46O26 • XCF3COOH
Formula Weight
2703.3
Purity
≥95%
Formulation(Request formulation change)
A solid
Peptide Sequence
YGRKKRRQRRRKQIEIKKFK-OH
Solubility(Learn about Variance in Solubility)
- Water: Soluble
SMILES
OC(C(F)(F)F)=O.O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(N)=O)C(N[C@@](C(N[C@@H](CCC(O)=O)C(N[C@@](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCCCN[H])C(O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(O)C=C2)N[H]
InChi Code
InChI=1S/C119H212N46O26.C2HF3O2/c1-5-67(3)93(111(188)160-78(34-14-20-56-124)100(177)152-77(33-13-19-55-123)106(183)163-88(65-69-28-8-7-9-29-69)110(187)162-87(113(190)191)35-15-21-57-125)165-109(186)86(48-51-92(170)171)161-112(189)94(68(4)6-2)164-108(185)85(47-50-90(128)168)159-99(176)76(32-12-18-54-122)151-101(178)79(37-23-59-142-115(131)132)154-103(180)81(39-25-61-144-117(135)136)155-104(181)82(40-26-62-145-118(137)138)157-107(184)84(46-49-89(127)167)158-105(182)83(41-27-63-146-119(139)140)156-102(179)80(38-24-60-143-116(133)134)153-98(175)75(31-11-17-53-121)150-97(174)74(30-10-16-52-120)149-96(173)73(36-22-58-141-114(129)130)148-91(169)66-147-95(172)72(126)64-70-42-44-71(166)45-43-70;3-2(4,5)1(6)7/h7-9,28-29,42-45,67-68,72-88,93-94,166H,5-6,10-27,30-41,46-66,120-126H2,1-4H3,(H2,127,167)(H2,128,168)(H,147,172)(H,148,169)(H,149,173)(H,150,174)(H,151,178)(H,152,177)(H,153,175)(H,154,180)(H,155,181)(H,156,179)(H,157,184)(H,158,182)(H,159,176)(H,160,188)(H,161,189)(H,162,187)(H,163,183)(H,164,185)(H,165,186)(H,170,171)(H,190,191)(H4,129,130,141)(H4,131,132,142)(H4,133,134,143)(H4,135,136,144)(H4,137,138,145)(H4,139,140,146);(H,6,7)/t67-,68-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,93-,94-;/m0./s1
InChi Key
OUQZHHJZEOMXDH-UTLSFRJRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36729-5 |
|---|---|
| Supplier Part Number | 36729-5 |
| UM | EA |
| UNSPSC | 12352100 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/36729m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |