We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman BMS 502
NETA PART: | CAYM-39303-50 |
MFG.PART: | 39303-50 |
UNSPSC: | 12352100 |
Manufacturer: | Cayman |
Product Description
BMS 502 is an inhibitor of diacylglycerol kinase α (DGK-α), DGK-ζ, and DGK-ι (IC50s = 0.0046, 0.0021, and 0.0026 µM, respectively).1 It is selective for these DGKs over DGK-β, DGK-γ, and DGK-κ (IC50s = 1, 0.68, and 4.6 µM, respectively). BMS 502 increases levels of IFN-γ and phosphorylation of ERK in isolated human whole blood (EC50s = 0.28 and 0.52 µM, respectively). It also increases the proliferation of CD8+ T cells (EC50 = 0.065 µM), which express DGK-α and DGK-ζ but not DGK-ι. BMS 502 (0.3-10 mg/kg) increases the frequency of CD69+CD8+ T cells when administered in combination with the peptide antigen SIINFEKL in OT I mice, which express modified murine T cell receptors that recognize SIINFEKL.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 10 mg/ml
- DMSO: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-39303-50 |
---|---|
Supplier Part Number | 39303-50 |
UM | EA |
UNSPSC | 12352100 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/39303m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 2407854-18-4 |