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Cayman FEN1-IN-4
Cayman FEN1-IN-4 - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$286.00
Your Price
$286.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-37790-10 |
| MFG.PART: | 37790-10 |
| UNSPSC: | 12352100 |
| Manufacturer: | Cayman |
Product Description
FEN1-IN-4 is an inhibitor of flap endonuclease 1 (FEN1; IC50 = 30 nM for FEN1-336Δ).1 It also inhibits exonuclease 1 in a concentration-dependent manner. FEN1-IN-4 (10 µM) inhibits ATP-induced mitochondrial DNA (mtDNA) fragmentation and levels of cytosolic mtDNA in LPS-primed primary mouse bone marrow-derived macrophages (BMDMs).2 It also inhibits ATP-induced phosphorylation of STING in LPS-primed wild-type and Nlrp3-/- primary mouse BMDMs. FEN1-IN-4 (40 mg/kg) decreases peritoneal levels of IL-1β and neutrophil and monocyte infiltration in a mouse model of alum-induced peritonitis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-(cyclopropyl
CAS Number
1995893-58-7
Synonyms
- FEN1 Inhibitor 4
- Flap Endonuclease 1-IN-4
- Flap Endonuclease 1 Inhibitor 4
Molecular Formula
C12H12N2O3
Formula Weight
232.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- Methanol: Soluble
SMILES
O=C1C2=C(N(CC3CC3)C(N1O)=O)C=CC=C2
InChi Code
InChI=1S/C12H12N2O3/c15-11-9-3-1-2-4-10(9)13(7-8-5-6-8)12(16)14(11)17/h1-4,8,17H,5-7H2
InChi Key
JAFLWTUYSKADJS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37790-10 |
|---|---|
| Supplier Part Number | 37790-10 |
| UM | EA |
| UNSPSC | 12352100 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/37790m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 1995893-58-7 |