Cayman R 715 (trifluoroacetate salt)

BX-320 is an inhibitor of the serine/threonine kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1; IC₅₀ = 30 nM). It is selective for PDK1 over a panel of 10 additional kinases (IC₅₀s = >820 nM for all). BX-320 inhibits Akt and p70S6K1 phosphorylation in PC3 cells (IC₅₀s = 1-3 µM). It induces apoptosis in, and inhibits the growth of, MDA-MB-468 breast cancer cells (IC₅₀s = 0.5 and 0.6 µM, respectively), as well as inhibits cell growth in a panel of cancer cells (IC₅₀s = 0.12-1.2 µM). BX-320 (200 mg/kg) inhibits the growth of lung tumors in a LOX melanoma mouse model of blood-borne metastasis.

WARNING This product is not for human or veterinary use.