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Cayman Gentamicin ELISA Standard
NETA PART: | CAYM-400558-1 |
MFG.PART: | 400558-1 |
UNSPSC: | 41116104 |
Manufacturer: | Cayman |
Product Description
CCT245737 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 1.3 nM). It is selective for Chk1 over Chk2 (IC50 = 2,440 nM). CCT245737 inhibits G2 checkpoint arrest induced by etoposide (Item No. ) in HT-29 colon cancer cells (IC50 = 30 nM). In vivo, CCT245737 (300 mg/kg) inhibits Chk1 autophosphorylation induced by gemcitabine (Item No. ) in an SW620 colon cancer mouse xenograft model. It reduces tumor volume when administered alone or in combination with gemcitabine in an HT-29 mouse xenograft model. CCT245737 (150 mg/kg) reduces inguinal, brachial/axillary, and mesenteric lymph node weights in the Eμ-Myc driven transgenic mouse transplant model of lymph gland-infiltrating B cell lymphoma.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: soluble
Shipping & Storage Information
SKU | CAYM-400558-1 |
---|---|
Supplier Part Number | 400558-1 |
UM | EA |
UNSPSC | 41116104 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/400558m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |