Cayman 2-(2-Chlorophenyl)-2-nitrocyclohexanone

Product Description

Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH₂ (Item No. ) to PGD₂ (Item No. ), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory cells, and inhibition of platelet aggregation.^,, There are two types of PGDS: lipocalin PGDS (L-PGDS; Item Nos. | ) and hematopoietic PGDS (H-PGDS; Item No. ). H-PGDS is found in peripheral tissues and immune cells, including Th2 cells, antigen-presenting cells, mast cells, megakaryocytes, and eosinophils, where it is localized to the cytosol. H-PGDS activity is increased by a variety of stimuli, including LPS, anti-IgE antibodies, phorbol 12-myristate 13-acetate (TPA; Item No. ), ionomycin (Item No. ), and inflammatory cytokines such as IL-13, IL-3, or IL-4. siRNA silencing of Hpgds decreases LPS-induced production of PGD₂ in mouse bone marrow-derived macrophages (BMDMs). Transgenic overexpression of HPGDS in mice increases croton oil-induced ear swelling and PGD₂ production, and genome-wide deletion of Hpgds exacerbates hypotension and vascular permeability in a mouse model of anaphylaxis.^, H-PGDS protein levels are increased in the nasal mucosa of patients with allergic rhinitis, and HPGDS SNPs have been found in individuals with asthma.^, Cayman’s Prostaglandin D Synthase (hematopoietic-type; human) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes H-PGDS at ^~24 kDa from human and mouse samples.

WARNING This product is not for human or veterinary use.

Technical Information