Cayman GPX2 (human, recombinant)

N^ε-(1-Carboxymethyl)-L-lysine-d₃ (CML-d₃) is intended for use as an internal standard for the quantification of CML (Item No. ) by GC- or LC-MS. CML is an advanced glycation end product (AGE), produced by the oxidative modification of glycated proteins during oxidative stress.^,, Levels of CML increase with aging and during diabetes, cancer, vascular disease, and other pathologies marked by oxidative stress.^,, CML activates the membrane-bound receptor for AGEs (RAGE), triggering signaling through MAPKs and NF-κB, whereas truncation of RAGE produces a soluble protein that binds CML and reduces signaling.^,

WARNING This product is not for human or veterinary use.