Cayman 5,7,3,4,5-Pentamethoxyflavone

5,7,3,4,5-Pentamethoxyflavone is a flavonoid that has been found in M. paniculata and has diverse biological activities.^1,2,3,4 It inhibits pancreatic lipase in a cell-free assay and reduces lipid accumulation in 3T3-L1 adipocytes in a concentration-dependent manner.¹ 5,7,3,4,5-Pentamethoxyflavone inhibits transactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) in a reporter assay using HEK293T cells when used at concentrations of 10, 25, or 50 µM.² It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and GES-1 cells.³ 5,7,3,4,5-Pentamethoxyflavone (25 µM) sensitizes cisplatin-resistant A549 non-small cell lung cancer (NSCLC) cells to the DNA-crosslinking agent cisplatin (Item No. 13119).² In vivo, 5,7,3,4,5-pentamethoxyflavone (5 mg/kg) decreases blood glucose levels and renal fibrosis in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).⁴

WARNING This product is not for human or veterinary use.