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GenScript DXd ADC Pharmacokinetic ELISA Kit
GenScript DXd ADC Pharmacokinetic ELISA Kit - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$498.00
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$498.00
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NETA PART: | GSCRPT-L00972 |
MFG.PART: | L00972 |
UNSPSC: | 41116126 |
Manufacturer: | GenScript USA Inc |
GenScript DXd-ADC technology is composed of an enzymatically cleavable tetrapeptide–based linker, a novelexatecan derivative (DXd) payload and an antibody drug [1–3]. For example, Trastuzumab deruxtecan (DS-8201a, T-DXd) is an DXd antibody-drug conjugate (DXd-ADC), composed of an enzymatically cleavable maleimide glycynglycyn-phenylalanyn-glycyn (GGFG) peptide linker, DXd, and an anti-HER2 antibody. DXd is a more potent DNA topoisomerase I (TOP1) inhibitor which has been proved to be cytotoxic to human cancer cell lines, such as KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 [2]. The DXd-ADC technology has a linker stable in plasma, a payload with a short systemic half-life, and an ADC in which the average drug-to-antibody ratio (DAR) can be optimized up to 8 for each target [1–6].
GenScript has comprehensively developed and validated the DXd ADC Pharmacokinetic ELISA Kit for the quantitative measurement of DXd-ADC in cynomolgus monkeyserum and plasma. This kit based on the ICH M10 and the FDA bioanalytical method validation guidance for industry, ensuring its precision, accuracy, dilutional linearity, specificity, selectivity, stability, and hook effect were acceptable [7-10]. The ELISA kit is a validated tool for DXd-ADC quantification in biological matrices for drug research and development. - GSCRPT (Additional S&H or Hazmat Fees May Apply)
SKU | GSCRPT-L00972 |
---|---|
Supplier Part Number | L00972 |
UM | EA |
UNSPSC | 41116126 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |
Hazardous | Y |