Sigma-Aldrich Tamoxifen, 1g

Sigma-Aldrich Tamoxifen, 1 g Net Content, C26H29NO, Powder Form, White to Off-White, >=99 %, 2 to 8 deg C, Melting Point: 97 to 98 deg C, (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-4-(1,2-Diphenyl-1-butenyl)phenoxy-N,N-dimethylethylamine. Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells - SIALGSK (Additional S&H or Hazmat Fees May Apply)