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Cayman Ripasudil (hydrochloride hydrate)
NETA PART: | CAYM-19920-10 |
MFG.PART: | 19920-10 |
UNSPSC: | 12352100 |
Manufacturer: | Cayman |
Product Description
Ripasudil is an inhibitor of Rho-associated kinase 1 (ROCK1) and ROCK2 (IC50s = 51 and 19 nM, respectively).1 It is selective for ROCK1 and ROCK2 over protein kinase A catalytic subunit α (PKACα) and PKC (IC50s = 2,100 and >10,000 nM, respectively). Ripasudil (0.4%) reduces intraocular pressure in cynomolgus monkey to a greater extent than the prostaglandin FP receptor agonist latanoprost (Item No. 16812). It increases the outflow facility of the aqueous humor in rabbit eyes when administered in a 0.4% solution. Ripasudil (0.4%) decreases intraocular pressure, retinal ganglion cell death, and thinning of inner retinal layers, as well as improves retinal function, in an excitatory amino acid transporter 1 (EAAT1) knockout mouse model of normal tension glaucoma.2 Formulations containing ripasudil have been used in the treatment of glaucoma and ocular hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
- K-115
- DMF: Slightly soluble
- DMSO: 30 mg/ml
- PBS (pH 7.2): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-19920-10 |
---|---|
Supplier Part Number | 19920-10 |
UM | EA |
UNSPSC | 12352100 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19920m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 887375-67-9 |