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Cell Signaling Rb (4h1) Mouse mAb (Pe Conjugate)
Cell Signaling Rb (4h1) Mouse mAb (Pe Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
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$435.00
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$435.00
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| NETA PART: | CSIG-14731S |
| MFG.PART: | 14731S |
| UNSPSC: | 41116111 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl (50 tests) |
| Reactivity | H Mk B Pg |
| Sensitivity | Endogenous |
| Source/Isotype | Mouse IgG2a |
| Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:50} |
| Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze. |
| Specificity/Sensitivity | Rb (4H1) Mouse mAb (PE Conjugate) detects endogenous levels of total Rb protein. The antibody does not cross-react with the Rb homologues p107 or p130, or with other proteins. |
| Species Reactivity | Human, Monkey, Bovine, Pig |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with an Rb-C terminal fusion protein containing residues 701-928 of human Rb. |
| Background | The retinoblastoma tumor suppressor protein Rb regulates cell proliferation by controlling progression through the restriction point within the G1-phase of the cell cycle (1). Rb has three functionally distinct binding domains and interacts with critical regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase, and proteins with a conserved LXCXE motif (2-4). Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression (5). Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation (6). Specificity of different CDK/cyclin complexes has been observed in vitro (6-8) and cyclin D1 is required for Ser780 phosphorylation in vivo (9). |
| SKU | CSIG-14731S |
|---|---|
| Supplier Part Number | 14731S |
| UM | UNIT |
| UNSPSC | 41116111 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | +4C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |